Chisasibi (Cree: ᒋᓴᓯᐱ, Cisasipi "Great River") is a village on the eastern shore of James Bay, in the Eeyou Istchee territory in northern Quebec, Canada. It is situated on the south shore of La Grande River (the Grand River), less than 10 km (6.2 mi) from the river's mouth. Chisasibi is one of nine Cree villages in the region, and is a member of the Grand Council of the Crees of Quebec. The territory surrounding Chisasibi is part of the Municipality of Baie-James, of which parts are jointly managed with the Cree Regional Authority.
The surface area of the town is 491.63 square kilometres (189.82 sq mi). The surface area of Chisasibi Cree Territory Category I Land (land exclusively for Cree use) is 828.18 square kilometres (319.76 sq mi).